巴斯皮龙的副作用和认知益处:系统性审查和元分析
1Mental Health Center and Laboratory of Psychiatry, West China Hospital of Sichuan University, 610041, Chengdu, China.
Heliyon
|April 11, 2024
概括
巴斯皮龙是一种5-HT1A受体激动剂,可能会引起头,便秘和胃. 然而,它显著改善了视觉学习,记忆,逻辑推理和注意力等认知功能,提供了潜在的治疗益处.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 精神病学是一个精神病学.
背景情况:
- 认知障碍是各种疾病的常见症状,有效的治疗选择有限.
- 作为5-HT1A受体激动剂的巴斯皮龙在治疗不同疾病方面表现出潜力,但其副作用概况和认知效应需要进一步阐明.
- 了解buspirone不良事件和认知益处之间的平衡对于其临床应用至关重要.
研究的目的:
- 为了全面评估buspirone在各种疾病中的副作用和认知益处.
- 综合随机临床试验的证据,以清楚地概述buspirone在认知领域的安全性和有效性.
- 为了确定buspirone治疗可能增强的特定认知功能.
主要方法:
- 在主要数据库 (PubMed,Embase,Web of Science,Cochrane) 进行了系统的文献搜索,寻找符合条件的随机临床试验.
- 包括报告不良事件和认知表现的研究.
- 进行了元分析,用于二分法变量使用几率比率 (OR),用于连续变量使用效果大小 (g),以95%的置信区间 (CI).
主要成果:
- 与安慰剂相比,巴斯皮龙与头 (OR=4.66),便秘 (OR=4.11) 和胃困扰 (OR=1.97) 的增加率有关.
- 总的来说,巴斯皮龙显示出显著的认知效益 (g=0.20),视觉学习和记忆 (g=0.49),逻辑推理 (g=0.42) 和注意力 (g=0.37) 的显著改善.
- 在安慰剂组中没有观察到显著的认知益处.
结论:
- 布斯皮龙与特定的副作用有关,包括头,便秘和胃困扰,在各种疾病背景下.
- 尽管有潜在的不良事件,巴斯皮龙对认知功能,特别是记忆,推理和注意力表现出显著的积极影响.
- 布斯皮龙代表了管理认知缺陷的潜在治疗选择,需要进一步调查其风险-益处概况.
更多相关视频
07:02A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
Published on: February 11, 2019
9.8K
04:33Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
673
相关概念视频
01:29Anxiolytic Drugs: Benzodiazepines and Buspirone
721
Benzodiazepines are a class of anxiolytic drugs known for their rapid efficacy and high therapeutic-to-lethal dose ratio, but with a potential risk of drug dependence. These drugs are lipophilic, allowing for rapid absorption after oral administration, eventually reaching the central nervous system (CNS). Once in the CNS, benzodiazepines bind to the allosteric site of the GABAA receptor. This binding enhances the inhibitory effects of the neurotransmitter GABA. By doing so, they prevent...
721
01:14CNS Depressants: Barbiturates and Benzodiazepines
258
CNS depressants include drugs from the category of barbiturates and benzodiazepines. They are valuable medications for managing anxiety disorders and insomnia. Barbiturates, once used to induce and maintain sleep, have been replaced mainly by benzodiazepines due to barbiturate's toxicity, tolerance, and overdose risks. They interact with GABAA receptors, leading to sedation at low doses and potentially coma and death at higher doses. Phenobarbital, a long-acting barbiturate, possesses...
258
01:26Anxiolytic Drugs: Overview
292
Anxiolytic drugs are vital in managing anxiety disorders by effectively alleviating symptoms such as excessive fear, tachycardia, and tremors. There are several classes of anxiolytic medications, each with unique mechanisms of action and potential side effects.
Primary Types of Anxiolytic Drugs
1. Benzodiazepines:
Benzodiazepines bind to the GABA-A receptor in the brain, enhancing GABA's interaction. This action reduces neurotransmission, effectively blocking anxiety-associated limbic...
Primary Types of Anxiolytic Drugs
1. Benzodiazepines:
Benzodiazepines bind to the GABA-A receptor in the brain, enhancing GABA's interaction. This action reduces neurotransmission, effectively blocking anxiety-associated limbic...
292
01:27Adrenergic Antagonists: Pharmacological Actions of β-Receptor Blockers
794
β-receptor blockers significantly impact the cardiovascular system by counteracting catecholamine-induced sympathetic responses. These medications decrease heart rate, contractility, and cardiac output, potentially leading to cardiac depression, life-threatening bradycardia, and death. Therapeutically, β-blockers function as mild antihypertensives and are utilized in treating angina pectoris and cardiac arrhythmias. However, nonselective β-blockers inhibit β2-receptors in...
794
01:54The Placebo Effect
6.2K
The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
6.2K
01:23Antidepressant Drugs: MAOIs and Other Agents
227
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
227