在严重脊髓损伤后,Moleac 901对Wistar大鼠慢性阶段的影响
Dewa Putu Wisnu Wardhana1, Sri Maliawan2, Tjokorda Gde Bagus Mahadewa2
1Neurosurgery Division, Department of Surgery, Faculty of Medicine, Universitas Udayana, Udayana University Hospital, 80361, Badung, Indonesia.
Heliyon
|April 11, 2024
概括
在患有慢性脊髓损伤 (SCI) 的老鼠中,MLC901治疗改善了运动功能,并减少了细胞死亡标志物. 这种植物药物增强神经前体细胞环境,促进严重SCI后的恢复.
科学领域:
- 神经科学是一个神经科学.
- 再生医学是一种再生医学.
- 药理学 药理学是指药理学的学科.
背景情况:
- MLC901是一种植物药物,支持神经前体细胞的增殖和分化.
- 本研究研究了MLC901对慢性阶段严重脊髓损伤 (SCI) 的影响.
研究的目的:
- 评估MLC901对SCI后病原体和运动功能的影响.
- 为了研究MLC901对NG2,酶-3,IL-10表达水平的影响.
主要方法:
- 一个随机的测试后仅对照组设计被用于18只Wistar大鼠.
- 鼠被分为正常控制,负控制和治疗组 (每组n=6).
- MLC901被给予治疗组,以评估其影响.
主要成果:
- MLC901显著降低了NG2和caspase-3的表达,同时增加了IL-10水平.
- 治疗组的Basso,Beattie和Bresnahan (BBB) 评分有所改善,这表明运动功能得到改善.
- MLC901与IL-10具有强烈的正相关性,与NG2和caspase-3表达具有负相关性.
结论:
- MLC901积极影响慢性SCI的运动和组织病理结果.
- 益处归因于抑制的滑症,神经亡和神经炎症.
- MLC901显示出治疗慢性脊髓损伤的潜力.
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