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母亲的童年逆境和婴儿表观遗传衰老:在怀孕期间通过不安睡眠来适度
David W Sosnowski1, Darlynn M Rojo-Wissar2,3, Gang Peng4
1Department of Mental Health, Johns Hopkins Bloomberg School of Public Health.
Developmental psychobiology
|April 11, 2024
概括
孕妇的童年逆境和怀孕期间的不安睡眠相互作用,加速婴儿的表观遗传衰老. 这一发现突显了早期生活压力和母亲睡眠对后代表观遗传学的综合影响.
科学领域:
- 发育表观遗传学 发育表观遗传学
- 围产期心理学 围产期心理学
- 孕产妇健康 孕产妇健康
背景情况:
- 母亲的不良童年经历 (ACE) 与不良健康结果有关.
- 母亲ACE对婴儿表观遗传学的影响,特别是表观遗传加快年龄,需要进一步研究.
- 怀孕期间母亲的睡眠可能会改变ACE对后代的影响.
研究的目的:
- 检查母亲ACE和婴儿表观遗传加快年龄之间的关联.
- 调查孕妇在怀孕期间的不安睡眠是否能缓和这种关联.
主要方法:
- 分析了332个母婴二合体.
- 母亲的ACE和不安睡眠是在第二个三个月内自我报告的.
- 婴儿的表观遗传年龄估计使用静脉内皮细胞和五个表观遗传钟的DNA甲基化.
主要成果:
- 没有独立观察到母亲ACE或不安睡眠的主要影响.
- 母亲ACE和不安睡眠之间的显著相互作用预测了婴儿表观遗传年龄加速 (EPIC妊娠年龄钟).
- 出生于报告ACE和不安睡眠的母亲的婴儿表现出加速表观遗传衰老.
结论:
- 孕妇的童年逆境和怀孕期间的不安睡眠可能共同影响婴儿的表观遗传衰老.
- 这种相互作用表明,通过早期生活压力和母亲睡眠影响后代表观遗传学的潜在途径.
- 需要进一步的研究来阐明这种关联背后的机制.
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