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在临床前模型中脑血管功能障碍和抑郁症状:从范围审查的见解

Nithin J Menon¹, Clara Sun¹, Jashnoor Chhina¹

¹Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada.

Journal of applied physiology (Bethesda, Md. : 1985)

|April 11, 2024

概括

脑血管功能障碍与动物模型中的抑郁症状有关,炎症和改变信号是关键因素. 需要更多的研究来理解因果关系和性别差异.

科学领域:

神经科学是一个神经科学.
心血管科学心血管科学
精神病学是一个精神病学.

背景情况:

现有的研究表明,脑血管功能障碍和抑郁症之间存在联系.
这种关系背后的机制路径在很大程度上仍未被探索.
临床前模型为研究这些联系提供了有价值的工具.

研究的目的:

对临床前动物模型进行范围审查,检查抑郁症状和脑血管功能障碍之间的关系.
识别现有文献中的潜在机械联系和知识差距.

主要方法:

在MEDLINE,EMBASE和Scopus数据库中进行了系统的搜索.
选择了15项符合纳入标准的临床前研究进行审查.
提取了有关关联,机械路径和方法方法的数据.

主要成果:

所有包括的研究报告说,在动物模型中,大脑血管功能障碍标志物和抑郁症状之间存在积极的关联.
发现的关键机械联系包括慢性炎症,血管氧化应激和改变的血清信号传递.
发现了重要的知识差距,特别是缺乏来自雌性动物的数据和对脑血管功能障碍的不一致评估.

结论:

在临床前模型中,大脑血管功能障碍和抑郁症状之间的相关关系是明显的.
慢性炎症,氧化应激和血清激素信号被强调为重要的机械因素.
未来的研究应该专注于确定因果关系,探索性别差异和标准化评估方法.

关键词:

脑血管疾病风险脑血管疾病风险认知障碍是一种认知障碍.抑郁症的模型抑郁症的模型抑郁症状的动物模型血管疾病是一种血管疾病.

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