电子喷涂的Eudragit RL100纳米颗粒配有Janus聚烯酸罗利片补丁,用于多相释放胺醇
Jianfeng Zhou1, Hao Pan2, Wenjian Gong1
1School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China. ydg017@usst.edu.cn.
Nanoscale
|April 11, 2024
概括
一种新的电喷技术创造了用于药物输送的Janus纳米粒子. 这些纳米颗粒提供双相药物释放,增强治疗效果和降醇输送的持续时间.
科学领域:
- 纳米技术 纳米技术
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
背景情况:
- 先进的纳米结构对于新型药物递送系统 (DDS) 是至关重要的.
- 开发具有控制释放配置文件的DDS仍然是一个重大挑战.
研究的目的:
- 开发一种用于制造双腔Janus纳米粒子的新型电喷过程.
- 描述开发的纳米粒子的纳米结构,药物状态和释放特征.
- 为了评估Janus纳米颗粒的*in vivo*治疗性能.
主要方法:
- 侧对侧电喷技术制造詹纳斯纳米粒子.
- 扫描电子显微镜 (SEM) 用于纳米结构分析.
- 为了药物聚合物的兼容性,使用X射线衍射 (XRD),差异扫描热度计 (DSC) 和减弱总反射率里埃变换红外光谱法 (ATR-FTIR).
- *体外*溶解试验用于药物释放动力学.
- *体内*动物研究用于治疗疗效的评估.
主要成果:
- 通过电喷成功制造集成的Janus纳米结构.
- 在纳米颗粒中确认了类醇的无形状态,表明良好的药物聚合物兼容性.
- 证明了一种双相药物释放特征,从聚烯 (PVP) 补丁中释放脉动性药物.
- 与传统纳米颗粒相比,体内研究显示治疗效果更快,治疗血度更长.
结论:
- 开发的电子喷雾方法可以创建具有可调节药物释放的Janus纳米粒子.
- 简斯纳米粒子提供双释放机制,改善治疗结果.
- 这项研究为先进的基于Janus结构的纳米DDS建立了新的过程结构性能关系.
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