通过皮肤进行的耳膜迷走神经刺激改变了中年和老年人的皮质刺激能力
Ashraf N H Gerges1, Lynton Graetz2, Susan Hillier1
1Innovation, Implementation and Clinical Translation (IIMPACT) in Health, Allied Health and Human Performance, University of South Australia, Adelaide, South Australia, Australia.
Psychophysiology
|April 11, 2024
概括
通过皮肤进行的耳道迷走神经刺激 (taVNS) 改变了老年人的运动皮层刺激能力. 较长的60分钟taVNS会话显著增加了抑制,而不是较短的30分钟会话.
科学领域:
- 神经科学是一个神经科学.
- 神经调节是一种神经调节.
- 老年学是一门学科.
背景情况:
- 越来越多的临床兴趣是通过皮肤进行耳道迷走神经刺激 (taVNS).
- 塔VNS对皮质刺激性的影响,以及持续时间是否重要,尚未完全理解.
- 调查taVNS对中年和老年人的影响对于潜在的治疗应用至关重要.
研究的目的:
- 为了确定taVNS是否会改变老年人初级运动皮层 (M1) 刺激能力.
- 评估刺激持续时间 (30分钟而不是60分钟) 是否调节taVNS效应.
- 为了评估一个常见的假冒协议对盲目的参与者的有效性.
主要方法:
- 这是一项双盲,随机,交叉,假控制的研究.
- 23名健康的老年人接受了活跃的taVNS (30分钟和60分钟) 和假的taVNS (30分钟).
- 经磁刺激 (TMS) 评估了M1刺激性;不良事件和生理措施被监测.
主要成果:
- 与假药相比,60分钟的taVNS显著增加了短时间内皮层抑制 (p=.002) 和短时间内皮层促进 (p=.014) 的显著降低.
- 30分钟的taVNS没有显著改变M1的兴奋能力.
- taVNS是安全的,耐受性很好,心率或血压没有显著变化. 蒙蔽是部分有效的,有96%的人检测到活跃的刺激.
结论:
- 在中年和老年人中,taVNS可以调节M1皮层刺激性.
- 塔VNS对皮层刺激性的影响取决于刺激的持续时间.
- 塔VNS似乎增强了GABAergic抑制并降低了谷氨酸活性,这表明其作用的神经化学基础.
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