低分子量肝素在头部和部的脚式片重建中的救援:一项前性队列研究
Smriti Panda1, Vimmi Gautam1, Sandipta Mitra1
1Department of Otorhinolaryngology and Head and Neck Surgery, All India Institute of Medical Sciences, New Delhi, India.
The Journal of laryngology and otology
|April 11, 2024
概括
低分子量肝素 (LMWH) 的全身用药可以在头部和部片重建中逆转或停止静脉妥协. 早期的LMWH救援显著减少了膜亡和相关并发症.
科学领域:
- 整形外科 整形外科 整形外科
- 头部和部手术 头部和部手术
- 血管外科 血管外科
背景情况:
- 静脉妥协是头部和部缺陷的局部区域片重建的一个重要并发症.
- 及时管理至关重要,以防止片故障和相关的发病率.
- 药理学剂在挽救损坏的片中的作用需要进一步研究.
研究的目的:
- 评估全身低分子量肝素 (LMWH) 在管理头部和部重建中的局部区域片的静脉妥协方面的疗效.
- 评估LMWH对片存活率和并发症发生率的影响.
主要方法:
- 一项前性研究涉及患者在头部和部板重建中发生静脉妥协.
- 该病例组接受了全身低分子量肝素 (dalteparin) 作为救援.
- 用LMWH治疗的患者和对照组之间的结果进行了比较.
主要成果:
- 在47名因静脉损伤而接受LMWH治疗的患者中,48.9%的患者经历了损伤的逆转或不进展.
- 与对照组相比,LMWH组的部分或完整死病发病率明显较低 (p=0.002).
- 在没有响应LMWH的患者中,23人 (23/43,53.5%) 经历了部分或完全的膜缩.
结论:
- 早期服用低分子量肝素作为救援疗法,可以显著减少头重建中的关联发病率.
- LMWH在逆转或停止静脉损害方面表现出潜力,从而改善片生存结果.
相关概念视频
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
689
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
689
01:16Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
408
Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
One of the advantages of...
408