红细胞分布宽度在患有与心脏病相关的肺动脉高血压的儿童中的预测值
Doaa El Amrousy1, Mona Hashem1, Hassnaa Hassan1
1Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta, Egypt.
Cardiology in the young
|April 11, 2024
概括
红细胞分布宽度在患有肺动脉高血压和先天性心脏病 (PAH-CHD) 的儿童中升高. 较高的红细胞分布宽度预测了这些儿童的死亡率,提供了一个简单,具有成本效益的标志物.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 血液学 血液学 血液学
- 关键护理医学 关键护理医学
背景情况:
- 肺动脉高血压 (PAH) 是先天性心脏病 (CHD) 的严重并发症,导致显著的发病率和死亡率.
- 红细胞分布宽度 (RDW) 的增加与患有严重心血管疾病 (包括肺高血压) 的患者的死亡风险增加有关.
- 在儿科PAH-CHD中RDW的预测价值还没有完全阐明.
研究的目的:
- 评估RDW在被诊断为PAH-CHD的儿童中的预测能力.
- 调查RDW与儿科PAH-CHD患者各种临床和心声学参数之间的相关性.
主要方法:
- 一组60名患有PAH-CHD的儿童与60名患有CHD但没有PAH的儿童进行了比较.
- 对所有参与者进行了标准心电图和心电回声图评估.
- 红细胞分布宽度是用Coulter® LH 700分析仪测量全血细胞计的一部分.
主要成果:
- 与对照组相比,患有PAH-CHD的儿童的RDW显著增加 (P < 0.05).
- 在RDW和平均肺动脉压力之间观察到显著的正相关性.
- RDW已成为儿科PAH-CHD死亡率的独立预测因子,截止值≥17.6%表明最高风险.
结论:
- 与没有PAH儿童相比,PAH-CHD儿童的RDW显著增加.
- RDW作为一个具有成本效益和易于获得的预测标志物用于PAH-CHD的儿科患者的死亡率.
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