过度的雄激素暴露和恶性瘤的风险:一个队列研究
Ida M Heerfordt1, Josefine Windfeld-Mathiasen1, Kim Peder Dalhoff1,2
1Department of Clinical Pharmacology, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Andrology
|April 11, 2024
概括
男性雄激素使用者没有增加短期癌症风险,包括前列腺癌和乳腺癌. 这项研究表明,恶性瘤的发病率与普通人群相似,但需要进一步研究.
科学领域:
- 内分泌学和瘤学的内分泌学和瘤学.
- 公共卫生和流行病学
背景情况:
- 关于雄激素使用与癌症风险之间的关联,知识有限.
- 以前的建议将雄激素使用与前列腺癌和乳腺癌的风险增加联系起来.
研究的目的:
- 为了调查男性雄激素使用者的癌症发病率.
- 为了比较雄激素使用者和对照组之间的癌症率,特别是前列腺癌和乳腺癌.
主要方法:
- 一项包括1,189名通过反兴奋剂计划识别的男性雄激素使用者的队列研究.
- 每个用户与50个对照组 (共59450人) 相匹配,并追踪到2023年.
- 癌症发病率 (前列腺,乳腺或任何不包括非黑色素瘤皮肤癌) 是主要结局.
主要成果:
- 没有观察到总体癌症发病率的显著差异 (发病率比:1.05).
- 在随访期间,没有人被诊断出患有前列腺癌或乳腺癌.
- 在雄激素使用者中,恶性瘤的绝对风险与对照组相比较.
结论:
- 男性雄激素使用者不表现出总体癌症,前列腺癌或乳腺癌的短期风险增加.
- 这些发现表明,雄激素使用者和普通人群之间存在类似的绝对癌症风险.
- 限制包括样本大小和随访时间,不允许最终排除雄激素作为危险因素.
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