构建高性能同型和异质微凝组装生物的通用战略
Xinbin Xu1,2,3,4, Haofei Li1,2,3,4, Junlin Chen1,2,3,4
1School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510006, P. R. China.
Small methods
|April 11, 2024
概括
研究人员开发了先进的微凝组装 (MA) 生物墨水,用于3D生物打印. 这些新的生物墨水克服了传统材料的局限性,使高保真性组织印刷能够提高细胞活力和功能.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 在3D生物打印中使用3D生物打印
背景情况:
- 传统的水凝和微凝生物墨水难以实现高形状保真性并保持细胞活力/功能.
- 这一局限性限制了用于复杂组织复制的合格生物墨的开发.
研究的目的:
- 为构建高性能微凝组件 (MA) 开发一种通用战略.
- 为了提高先进的3D挤出生物打印应用的生物墨水性能.
主要方法:
- 通过以鱼为灵感的化学方法,利用甲基酸修饰的氨酸 (HA-EGCG) 进行表面涂层.
- 采用乙烯酸移植乙烯酸 (HA-PBA) 与HA-EGCG形成动态键,产生MA生物墨水.
- 已证明适用于各种微凝材料,用于创建同质和异质MA生物墨水.
主要成果:
- 开发的MA生物墨水表现出卓越的风湿性质,自我愈合能力和组织粘附性.
- 成功地实现了复杂结构的分层印刷,具有高保真度.
- 通过使用homo-MA和hetero-MA生物墨水进行药物测试,证明了乳腺癌器官的体外打印.
结论:
- 这一通用策略为构建用于挤出生物打印的高性能生物墨水提供了新的解决方案.
- MA生物墨水为复制复杂组织架构和功能提供了更好的性能.
- 该方法可以创建复杂的生物打印结构,用于诸如有机体建模和药物查等应用.
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