90岁以上的神经病理变化与19至40年前的睡眠时间有关:90+研究
Zarui A Melikyan1, Claudia H Kawas1,2,3, Annlia Paganini-Hill2
1Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA.
概括
老年人睡眠时间较长与几十年后神经病理变化发生的几率降低有关,包括边缘主导的与年龄有关的TDP-43脑病变神经病理变化 (LATE-NC) 和粉样β沉积物. 这表明睡眠可能在痴呆症相关的大脑变化的积累中发挥作用.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 老年学是一门学科.
背景情况:
- 长期睡眠时间与老年人神经病理变化之间的关系尚不清楚.
- 调查这种关联可以提供关于痴呆相关病理的积累的见解.
研究的目的:
- 研究90岁及以上的参与者自我报告的睡眠时间与神经病理变化之间的关联.
- 为了确定睡眠时间更长是否预测几十年后特定神经病理变化的几率较低,例如LATE-NC和粉样β沉积物.
主要方法:
- 来自90+研究的参与者自我报告的睡眠时间.
- 神经病理学评估是在死后进行的.
- 逻辑回归被用来估计几率比率 (OR) 和95%置信区间 (CI) 基于睡眠持续时间类别 (<7小时,7-8小时[参考],>8小时) 的神经病变变化.
主要成果:
- 在264名参与者中 (睡眠报告中的平均年龄为69岁,尸检中的平均年龄为98岁),更长的睡眠时间 (>8小时) 与与边缘主导的与年龄相关的TDP-43脑病变神经病理变化 (LATE-NC) 入 (OR=0.18) 和粉样β沉积 (OR=0.34) 的几率明显较低有关.
- 这些关联在睡眠自我报告后的19至40年后被观察到.
结论:
- 较长的自我报告睡眠时间与最老的老年人中与神经退行相关的关键神经病理变化发生的可能性降低有关.
- 这些发现表明,睡眠时间可能在几十年来痴呆相关神经病理的积累中起着保护作用.
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