患有骨髓灰质炎的儿童的血清环球蛋白:预测复发和预后
Zhi Jiang1,2, Wenjing Hu2, Zeshu Ning2
1Department of Pediatrics, Jinan University First Affiliated Hospital, Guangzhou, China.
Neurological research
|April 11, 2024
概括
患有肌痛性骨髓灰质炎 (MG) 的儿童血清环球蛋白水平升高表明复发风险更高,治疗结果更差. 这一发现凸显了全球蛋白作为儿童MG病例的潜在预后标志物.
科学领域:
- 儿科神经学 儿科神经学
- 免疫学 免疫学 免疫学
- 临床生物化学 临床生物化学
背景情况:
- 血清环球蛋白与炎症和免疫状况有关.
- 血清环球蛋白与儿童肌痛性骨髓灰质炎 (MG) 之间的关联尚不清楚.
研究的目的:
- 研究血清环球蛋白水平与患有肌痛性骨髓灰质炎 (MG) 的儿科患者的疾病复发和预后之间的关系.
主要方法:
- 一项回顾性队列研究包括148名患有MG的儿童和150名健康对照.
- 采用多变量后勤和考克斯回归模型来分析治疗结果和复发,评估球蛋白的影响.
主要成果:
- 与对照人群相比,患有MG的儿童的血球蛋白水平略高.
- 入院血球蛋白水平是复发的独立风险因素 (OR=1.233,p=0.018) 和受影响的无复发时间 (HR=0.552,p=0.007).
- 高血球蛋白水平 (>25.10) 预测治疗结果不佳 (HR=0.607,p=0.033) 并影响治疗计划 (OR=1.445,p=0.014).
结论:
- 儿科MG患者入院时血清环球蛋白水平升高预示着复发率的增加.
- 高血球蛋白水平与MG儿童的长期治疗疗效较差有关.
- 血清环球蛋白可以作为一个有价值的预后生物标志物,用于管理儿科肌痛严重症.
相关概念视频
Myasthenia Gravis: Diagnostic Tests
810
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
810
Myasthenia Gravis: Overview and Treatment
1.4K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
1.4K
Disorders of the Skeletal Muscle
939
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
939
Satellite Stem Cells and Muscular Dystrophy
2.0K
Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
2.0K
Immunological Memory
602
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
602


