与免疫抑制和COVID-19患者同时使用疫苗增强康复性血进行门诊治疗
Juan G Ripoll1, Sidna M Tulledge-Scheitel2, Anthony A Stephenson1
1Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, USA.
mBio
|April 11, 2024
概括
疫苗增强康复期血显著减少了免疫功能低下的门诊患者的COVID-19住院治疗. 这种"vax-plasma"疗法为面对不断演变的SARS-CoV-2变种的弱势群体提供了一个有前途的替代方案.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 免疫功能低下的患者对COVID-19疫苗的反应减弱,并且面临严重SARS-CoV-2感染的高风险.
- 新出现的SARS-CoV-2变种可以逃避单克隆抗体的中和,限制治疗选择.
- 从以前感染和接种疫苗的个人获得的COVID-19康复性血 ("vax-plasma") 正在研究疗效.
研究的目的:
- 评估vax-plasma在患有COVID-19的免疫功能低下的门诊患者中的临床益处.
- 为了比较接受vax-plasma和标准护理治疗的患者之间的住院率.
主要方法:
- 分析了386名被诊断为COVID-19的免疫功能低下的门诊患者的队列.
- 患者接受了标准的护理 (SOC) COVID-19疗法或SOC加高位数的vax-plasma.
- 住院率是主要的结果指标.
主要成果:
- 在vax-plasma组的住院率为2.2% (5/225),而SOC组的6.2% (10/161).
- 这意味着住院治疗的相对风险降低了65% (P = 0.046).
- 该研究主要包括接种疫苗的患者 (94%),限制了对未接种疫苗的患者的推断.
结论:
- 同时使用vax-plasma和COVID-19特定疗法显著降低了接种疫苗,免疫功能低下的COVID-19门诊患者的住院风险.
- 高滴度康复性血证明了作为抗体替代疗法的临床实用性,特别是在脆弱人群中对不断演变的SARS-CoV-2变体具有临床实用性.
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