与癌症相关的纤维细胞:在瘤进展,转移和向治疗中的多功能调解者
1Women's Reproductive Health Laboratory of Zhejiang Province, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, Zhejiang, China.
Cancer metastasis reviews
|April 11, 2024
概括
癌症相关纤维细胞 (CAF) 是瘤微环境 (TME) 中的关键参与者,影响瘤生长和扩散. 了解CAF多样性对于开发有效的向癌症疗法至关重要.
科学领域:
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
- 癌症研究 癌症研究
背景情况:
- 瘤微环境 (TME) 显著影响癌症的发病,进展和转移.
- 癌症相关纤维细胞 (CAFs) 是TME内的一个主要的细胞组成部分.
- CAFs表现出异质的起源和特性,影响瘤细胞相互作用.
研究的目的:
- 探索瘤微环境 (TME) 中癌症相关纤维细胞 (CAF) 的异质性.
- 阐明CAFs的不同起源和表型.
- 了解CAF在癌症进展和转移中的多方面的作用.
主要方法:
- 关于瘤微环境和癌症相关纤维细胞的现有文献的综述.
- 分析单细胞RNA测序数据以确定CAF表型.
- 检查CAF对瘤发生,茎形成,血管生成,免疫抑制,新陈代谢和转移的贡献.
主要成果:
- CAF来自各种细胞类型,包括纤维细胞,介质干细胞,脂肪细胞,细胞周细胞,内皮细胞和中皮细胞.
- 单细胞RNA测序揭示了不同的CAF表型,特别是肌纤维细胞CAF (myCAF),炎症CAF (iCAF) 和抗原呈现CAF (apCAF).
- CAF的异质性驱动着多种功能,包括促进瘤发生,癌症干,血管生成,免疫抑制,改变新陈代谢,促进转移.
结论:
- CAF的异质性是它们在TME中的多样性角色的关键因素.
- 针对TME内的CAF的向治疗对晚期癌症治疗具有重大前景.
- 对CAF亚型的进一步研究对于开发更精确,更有效的瘤向疗法至关重要.
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