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年轻乳腺癌幸存者的第二次原发性乳腺癌

Kristen D Brantley^1,2, Shoshana M Rosenberg³, Laura C Collins^4,5

¹Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.

|April 11, 2024

概括

没有致病变体的年轻乳腺癌 (BC) 幸存者具有较低的第二原发性BC (SPBC) 风险. 基因检测可以指导这些年轻女性的治疗和随访护理.

科学领域:

在瘤学瘤学.
遗传学遗传学是一个
流行病学流行病学

背景情况:

被诊断为原发性乳腺癌 (BC) 的年轻女性可能患第二次原发性BC (SPBC) 的风险更高.
了解这一人口群体中SPBC的累积发病率和风险因素对于个性化护理至关重要.

研究的目的:

估计40岁或更年轻时被诊断患有BC的妇女中SPBC的累积发病率.
确定与该人群中SPBC发展相关的临床风险因素.

主要方法:

一项前性队列研究,对1297名年龄在40岁或以下的妇女进行了前性队列研究,这些妇女被诊断患有0-III期BC.
时间到事件分析和细灰分布危险模型被用于评估SPBC风险.
数据包括人口统计,遗传检测结果,治疗和结果.

主要成果:

在685名女性中,随访时间平均为10年,其中17名 (2.5%) 患有SPBC.
对于非携带者来说,SPBC的10年风险为2.2%,对于致病变体的携带者来说为8.9%.
与侵袭性BC相比,SPBC风险在致病性变体携带者和具有原发性局部BC的患者中较高.

结论:

没有生殖系致病变体的年轻BC幸存者在10年内具有SPBC的低风险.
生殖线遗传检测结果可以为年轻BC患者的治疗决策和后续策略提供信息.

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