金属-药物协调纳米粒子和水凝用于增强交付
Ka-Ying Wong1,2, Zhenyu Nie3,4, Man-Sau Wong2,5,6
1Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, ON, N2L 3G1, Canada.
Advanced materials (Deerfield Beach, Fla.)
|April 11, 2024
概括
本综述探讨使用药物分子作为金属协调的配体,以创建用于药物输送的新型纳米材料. 与传统方法相比,这种方法提供了较高的药物与金属比率和较低的毒性.
科学领域:
- 纳米医学是一种纳米医学.
- 材料科学 材料科学 材料科学
- 药物运输 药物运输 药物运输
背景情况:
- 传统的纳米医药药物输送依赖于吸附或封装药物到纳米材料上.
- 许多当前的配送车辆含有高金属含量,引发了毒性问题,并阻碍了临床批准.
- 现有的方法通常涉及金属离子在金属有机框架和纳米粒子等材料中.
研究的目的:
- 总结最近在使用药物分子作为金属协调的配体在纳米材料和软材料合成的进展.
- 突出提高药物与金属比率以提高药物输送效率的策略.
- 讨论在新型药物输送系统中降低毒性的潜力.
主要方法:
- 将药物分子分类为小分子,核酸和蛋白质.
- 审查混合纳米材料的形成,包括纳米粒子和水凝.
- 检查向配体在混合材料上的接种,以提高有效性和降低毒性.
主要成果:
- 药物分子可以充当连接体,与金属协调形成混合纳米材料,具有高的药物与金属比率.
- 这些混合材料,包括纳米粒子和水凝,显示了针对药物输送的前景.
- 移植向配体可以进一步提高治疗疗效并降低材料毒性.
结论:
- 基于药物的配体策略为传统纳米材料药物输送提供了一个有希望的替代方案,可能克服毒性问题.
- 这些新型混合材料在治疗癌症,感染和炎症等疾病方面具有广泛的应用.
- 未来的研究应该专注于这些先进的药物输送系统的基础科学,材料开发和临床翻译.
相关概念视频
02:51Metal-Ligand Bonds
20.7K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
20.7K
00:56Extraction: Advanced Methods
446
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
446
01:19Complexation Equilibria: The Chelate Effect
513
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
513
01:21Drug Distribution: Tissue Binding
2.6K
Upon entering the systemic circulation, drugs can distribute into the interstitial and intracellular fluid of various tissue cells. This distribution is facilitated by the binding of drugs to different cellular components within tissues, which may lead to drug accumulation in specific areas. Drugs bound to tissue components serve as reservoirs that release free drugs back into the system, prolonging the drug's overall action. However, this accumulation can also result in local toxicity.
For...
For...
2.6K