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[精子DNA损伤与IVF-ET临床怀孕结果在不同BMI群体与正常常规精液检查之间的相关性]

Cheng-Yi Zheng^1,2, Yan Wen¹, Zhi-Wei Xue¹

¹Assisted Reproductive Center, Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China，Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong 250014, China .

Zhonghua nan ke xue = National journal of andrology

|April 11, 2024

概括

精子DNA碎片化 (DFI) 影响了IVF-ET怀孕的成功,特别是在超重的男性中. 男性年龄和BMI分别是正常和肥胖群体的关键因素,而HDS显示没有相关性.

科学领域:

生殖内分泌学生殖内分泌学
精子生物学精子生物学
在体外受精过程中受精.

背景情况:

肥胖和超重的情况越来越普遍,并可能影响男性生育能力.
精子DNA碎片化 (DFI) 和HDS是精子质量的新兴标志物.
身体质量指数 (BMI) 对精子DFI,HDS和体外受精-胚胎移植 (IVF-ET) 结果之间的关系的影响需要进一步研究.

研究的目的:

调查精子DFI,HDS和IVF-ET怀孕结果之间的相关性.
分析不同男性BMI类别 (正常,超重,肥胖) 的这些相关性.
确定与BMI和精子染色体完整性相关的IVF-ET成功的关键预测因素.

主要方法:

对199个IVF-ET周期的回顾性分析.
精子染色质结构分析使用流细胞计测量DFI和HDS.
统计分析以确定DFI,HDS,BMI,男性年龄和IVF-ET怀孕结果之间的相关性.

主要成果:

在超重人口中,精子DFI与IVF-ET怀孕有负相关性 (BMI 24.027.9 kg/m2).
在正常的BMI个体中 (18.523.9 kg/m2),男性年龄,而不是DFI,与怀孕结果有显著的相关性.
在肥胖人口中 (BMI ≥28.0 kg/m2),男性BMI,而不是DFI,与IVF-ET成功负相关.

结论:

男性的BMI显著调节精子DFI和IVF-ET结果之间的关联.
精子DFI仅在超重男性中与IVF-ET成功有关.
男性年龄和BMI是影响IVF-ET结果的关键因素,分别在正常和肥胖人群中.
在任何一个BMI组中,精子HDS与IVF-ET怀孕结果没有显著的相关性.

关键词:

男人体质指数;精子DNA碎片指数;精子高DNA稳定性;IVF-ET.

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