胎儿通过寿命对人类大脑的影响
Kristine B Walhovd1,2, Stine K Krogsrud1, Inge K Amlien1
1Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway.
eLife
|April 11, 2024
概括
较高的出生体重 (BW) 与整个生命中的大脑大小有关,但与大脑随时间的变化无关. 这种早期生长因子影响大脑储备,而不是维护,并具有潜在的终身益处.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 人类寿命研究研究 人类寿命研究
背景情况:
- 产前发育和胎儿生长对于长期健康至关重要.
- 胎内生长 (出生体重) 与终身大脑特征之间的关系尚不清楚.
- 了解基因与环境对这种关系的影响是很重要的.
研究的目的:
- 研究出生体重与大脑结构 (皮质表面积和体积) 之间的终身关联.
- 为了检查出生时的体重是否会影响整个生命中大脑的变化.
- 探索对出生体重与大脑结构关系的遗传和环境贡献.
主要方法:
- 对大脑MRI数据的纵向分析来自一个大队列 (N=5794) 跨越年龄为4至82.
- 包括单双双胞胎数据来解开遗传和环境因素.
- 长期随访 (长达8.3年) 进行了广泛的大脑成像 (12,088张MRI).
主要成果:
- 在出生体重和皮质表面积和体积之间发现了一致的,终身的积极关联.
- 随着时间的推移,出生体重和大脑变化之间没有明显的关联.
- 双胞胎分析表明,对出生体重与大脑结构的联系有部分环境影响.
结论:
- 正如出生体重所指出的产前生长,在人类一生中对皮质地形有着稳定而持久的影响.
- 出生的体重似乎影响大脑的储备能力,而不是其维护机制.
- 优化胎儿生长可能会增强终身大脑储备,在衰老过程中可能有利于大脑健康.
关键词:
衰老的衰老 衰老的衰老出生的体重出生时的体重.大脑大脑大脑的大脑大脑皮层 皮层 皮层发展发展发展发展发展.发育生物学是发展生物学.人类 人类 人类 人类 人类 人类 人类寿命长度 寿命长度神经科学 神经科学更多相关视频
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