毛囊刺激激素在非动物精子男性中的分布和积极预测值
Solomon Hayon1,2, Sai Kaushik Sr Kumar3, Daniel Greenberg1
1Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
The Journal of urology
|April 11, 2024
概括
卵泡刺激激素 (FSH) 水平在肥沃和不肥沃的男性之间显示出显著的差异,但标准值无法预测生育能力. 需要高FSH值才能可靠地预测次生育能力.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 安德罗学与人类学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 卵泡刺激激素 (FSH) 在精子生成中起着至关重要的作用.
- 评估FSH水平在男性生育能力评估中很常见,但其对生育状况的预测价值需要澄清.
研究的目的:
- 为了描述 FSH 分布在肥沃和不肥沃的非生殖精子男性.
- 评估各种FSH值在预测男性生育状态方面的有效性.
主要方法:
- 对1389名接受生育评估的非动物精子男性进行了回顾性队列研究.
- 根据总运动精子数量来分类为肥沃或亚肥沃的男性.
- 对FSH水平的分析和不同FSH值的正预测值 (PPV) 的计算.
主要成果:
- 中位数FSH在不孕期男性 (6.0mIU/mL) 显著高于生育期男性 (4.0mIU/mL).
- 在2.2至9.3mIU/mL之间的FSH值显示出低生育率的预测值很差 (PPV 0.49-0.59).
- 只有FSH水平高于第95百分位数 (12.1 mIU/mL) 才能提供临床上有用的预测能力.
结论:
- 标准FSH切断值不足以准确预测非动物精子男性的生育状况.
- 高的FSH值,特别是95百分位或以上的FSH值,更能表明子性.
- FSH测试是有价值的,但不应该作为独立的生育测试;极端值或不一致的结果需要进一步调查.
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