在全球反恐战争期间,从部署和非部署的美国服务人员手术肺部活检的粒子分析
Leslie Hayden1, James M Lightner2, Stacy Strausborger2
1Institute for Functional Materials and Devices, Lehigh University, Bethlehem, Pennsylvania, United States of America.
PloS one
|April 11, 2024
概括
在部署的服务人员中,吸入颗粒物暴露可能导致肺部疾病. 对肺部活检的分析显示,部署的个体中颗粒负载较高,主要是地质粘土,但没有识别出明显的部署特异性颗粒.
科学领域:
- 环境健康 环境健康
- 肺部医学 肺部医学
- 材料科学 材料科学 材料科学
背景情况:
- 吸入颗粒物对部署后美国军人部署到西南亚的肺部疾病的影响尚不清楚.
- 关于短期高水平颗粒物暴露和随后的肺部不良结果,存在数据缺口.
研究的目的:
- 调查部署服务成员和退伍军人 (DSM) 与非部署服务成员和退伍军人 (NDSM) 之间的手术肺活检中保留的无机颗粒的差异.
- 探索在DSM中发现的粒子和肺病理诊断之间的潜在关联.
主要方法:
- 使用场辐射扫描电子显微镜 (FE-SEM) 与能量分散式X射线光谱 (EDS) 检查了52次手术肺活检 (25 DSM,27 NDSMs).
- 量化和表征无机颗粒,比较DSM和NDSM之间的结果,并与他的病理学诊断相关联.
主要成果:
- 与NDSM相比,DSM的总颗粒数量更高,主要是地质粘土 (伊利石,高石),地,石英/,以及富含的酸盐.
- 从部署到"SWA-其他"地区的DSM进行的活检显示,颗粒数量高于伊拉克/阿富汗部署的颗粒数量,主要是由于不良.
- 没有明确的部署特定的粒子被确定,也没有粒子与特定的国家或诊断相关联.
结论:
- 部署服务人员肺部活检中的较高颗粒物负担表明环境暴露,但特定颗粒物与部署地点或疾病没有明确联系.
- 进一步比较部署和非部署组的研究对于了解颗粒物在服务成员肺部疾病中的作用至关重要.
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