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Updated: Jun 28, 2025

A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
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Published on: June 8, 2022

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人类氨基林1受体的冷EM结构与CGRP和Gs蛋白复合

Jianjun Cao1,2, Matthew J Belousoff1,2, Radostin Danev3

  • 1Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.

Biochemistry
|April 11, 2024
PubMed
概括

素基因相关 (CGRP) 受体是偏头痛的关键目标. 这项研究揭示了CGRP与氨酸1受体 (AMY1R) 与CGRP受体 (CGRPR) 的结合方式的结构差异,影响了药物开发.

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