在LGI1-抗体脑炎中复发的预测因素和临床特征
Lucia Campetella1, Antonio Farina1, Macarena Villagrán-García1
1From the French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (L.C., A.F., M.V.-G., M.V., M.B., A.V., G.P., V.R., B.J., J.H., S.M.-C.), Hospices Civils de Lyon; MeLiS - UCBL-CNRS UMR 5284 - INSERM U1314 (L.C., A.F., M.V.-G., M.B., A.V., B.J., J.H., S.M.-C.), Université Claude Bernard Lyon 1, France; Department of Neuroscience (A.F.), Psychology, Pharmacology and Child Health, University of Florence, Italy; Department of Biostatistics (N.T.), Hospices Civils de Lyon, France; Clinical Neurology (A.V.), Santa Maria Della Misericordia University Hospital, Azienda Sanitaria Universitaria Friuli Centrale (ASU FC); Department of Medicine (DAME) (A.V.), University of Udine, Italy; Neurology Department 2-Mazarin (D.P.), Hôpitaux Universitaires La Pitié Salpêtrière-Charles Foix, APHP; Brain and Spinal Cord Institute (D.P.), INSERM U1127/CNRS UMR 7255, Université Pierre-et-Marie-Curie, Universités Sorbonnes, Paris; Neurology Department (M.R.), Hôpital Pierre Paul Riquet, CHU de Toulouse; Neurology Department (E.C.), Centre Hospitalier Universitaire Gabriel Montpied, Clermont-Ferrand; Neurology Department (C.M.), Centre Hospitalier Universitaire de Bordeaux; Immunology Department (D.G.), Hôpital Lyon Sud, Hospices Civils de Lyon, France; and Stanford Center for Sleep Sciences and Medicine (S.M.-C.), Stanford University, Palo Alto, CA.
富含氨酸的质瘤失活1抗体 (LGI1-Ab) 自身免疫脑炎的复发,虽然通常较轻,但可以增加残疾. 早期的皮质类固醇治疗和解决认知功能障碍可能会降低复发风险.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 神经免疫学 神经免疫学
背景情况:
- 富含白的质瘤失活1抗体 (LGI1-Ab) 自身免疫脑炎影响15-25%的患者,可能导致进一步的残疾.
- 了解复发模式和预测因素对于管理LGI1-Ab脑炎至关重要.
研究的目的:
- 在临床上描述LGI1-Ab自身免疫脑炎的复发.
- 确定预测复发发生的因素.
主要方法:
- 在2005年至2022年期间,对210名被诊断患有LGI1-Ab脑炎的患者进行了回顾性图表审查.
- 复发定义为症状恶化或稳定后≥3个月出现新的症状.
主要成果:
- 14%的患者 (30/210) 经历了33次复发,第一次复发的中位时间为23.9个月.
- 复发的症状较少,并且最大修改的兰金尺度 (mRS) 比初始发作得分更低.
- 剩余的认知功能障碍和缺乏初始皮质类固醇治疗与复发风险增加有关.
结论:
- 在LGI1-Ab脑炎中复发可能发生几年后,通常较轻,但有助于累积残疾.
- 在最初的发作期间接受皮质类固醇治疗可能会降低未来复发的风险.
- 患有初始发作后残留认知功能障碍的患者面临复发的风险更高.
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