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Updated: Aug 15, 2026

Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro
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在星球细胞中NMDAR (2C) 删除缓解了LPS诱导的神经炎症和抑郁症

Ruyan Gao1, Tahir Ali2, Zizhen Liu1

  • 1State Key Laboratory of Chemical Oncogenomics, Guangdong Provincial Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, Guangdong, PR China, 518055.

International immunopharmacology
|April 11, 2024
PubMed
概括

从星球细胞中删除NR2C可以预防抑郁和神经炎症. 这突显了星细胞NMDARs在这些条件中的作用,并提出了新的治疗点.

关键词:
星球细胞是星球细胞.抑郁症 抑郁症 抑郁症没有NMDAR的药物.神经炎症是一种神经炎症.在 PI3K 信号传输中.

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Ligand-gated Ion Channels01:19

Ligand-gated Ion Channels

Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
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Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that include the...