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Multiple Sclerosis l: Introduction01:19

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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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在多发性硬化症中与事件相关的脱同步和同步.

Benjamin Bardel1, Moussa A Chalah2, Ruben Bensais-Rueda2

  • 1Univ Paris Est Créteil, Excitabilité Nerveuse et Thérapeutique (ENT), EA 4391, Créteil F-94010, France; Department of Clinical Neurophysiology, AP-HP, Henri Mondor University Hospital, DMU FIxIT, Creteil F-94010, France.

Multiple sclerosis and related disorders
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概括

患有多发性硬化症的患者表现出运动控制的改变,大脑激活延迟,运动后反应减少,通过脑电图 (EEG) 检测到. 这些变化可能涉及深层大脑结构中的补偿机制.

关键词:
与事件相关的脱同步.与事件相关的同步与事件相关的同步运动器功能 运动器功能多发性硬化症是多发性硬化症.传感器运动网络 传感器运动网络

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科学领域:

  • 神经科学是一个神经科学.
  • 临床神经学 临床神经学
  • 生物医学工程 生物医学工程

背景情况:

  • 在患有多发性硬化症 (pwMS) 的患者中,运动准备和执行经常受到损害.
  • 脑电图 (EEG) 可以评估神经过程,如与事件相关的脱同步 (ERD) 和与事件相关的同步 (ERS) 在自我节奏运动期间.

研究的目的:

  • 将pwMS中的ERD/ERS变化与健康对照 (HC) 中的变化进行比较.

主要方法:

  • 从13个 pwMS和10个HC中记录了60个频道的EEG,在自动节奏的手指运动中.
  • 分析了ERD和ERS参数 (延迟,持续时间,振幅) 在五个皮质区域的α和β频段.
  • 评估了临床和神经成像变量,包括深层大脑结构体积和病变负载.

主要成果:

  • 主要在β频段观察到pwMS的变化,显示ERD发病时间延迟,幅度缩短/增加.
  • 与执行功能和尾状核体积相关的β-ERD变化.
  • 贝塔-ERS的变化包括更短的持续时间,延迟发作或降低的幅度,与疲劳水平和胸膜体积有关.

结论:

  • 多发性硬化症与改变运动准备和执行有关,以延迟皮质激活 (ERD) 和β频段的运动后抑制 (ERS) 损害为特征.
  • 涉及深层大脑结构的潜在补偿机制可能是某些pwMS中保持临床表现的基础.