在西班牙南部的家养山羊中发现了Mycobacterium tuberculosis复合体
Débora Jiménez-Martín1, Ignacio García-Bocanegra2, María A Risalde3
1Departamento de Sanidad Animal, Grupo de Investigación en Sanidad Animal y Zoonosis (GISAZ), UIC Zoonosis y Enfermedades Emergentes ENZOEM, Universidad de Córdoba, Córdoba, Spain.
结核病 (TB) 在西班牙山羊中普遍存在,血清流行率超过22%. 密集农业和医院是危险因素,MTC菌株广泛传播,突出了对山羊种群的控制措施的需要.
科学领域:
- 兽医传染病 兽医传染病
- 动物传播疾病流行病学
- 菌根细菌感染的分子流行病学
背景情况:
- 结核病 (TB) 是一种由Mycobacterium tuberculosis complex (MTC) 细菌引起的动物性疾病,影响各种动物物种.
- 众所周知,山羊是MTC的存储库,但关于流通的菌株和流行率的数据仍然有限.
- 西班牙南部是牛和野生类动物的结核热点,使山羊种群成为研究的关键领域.
研究的目的:
- 确定南西班牙安达卢西亚山羊的血清流行率,空间分布,风险因素和MTCspoligotypes.
- 评估山羊在这种高风险地区的MTC维持和传播中的潜在作用.
- 为制定针对山羊结核病的有针对性的控制策略提供信息.
主要方法:
- 分析了来自80只山羊群的2155个血清样本,使用内部ELISA与P22蛋白质复合体.
- 应用通用估计方程模型来识别与MTC暴露相关的风险因素.
- 空间分析以检测MTC感染的显著集群.
- 用MTC分离物体的spoligotyping来表征循环的菌株.
主要成果:
- 在山羊中发现了22.3%的真正血清流行率,90%的羊群受到影响.
- 强化/半强化管理系统和医院监护所的存在被确定为风险因素.
- 在安达卢西亚东部检测到MTC感染的显著空间集群.
- 确定了16种MTC型,包括Mycobacterium caprae和Mycobacterium bovis,其中SB0157是最常见的.
结论:
- 在西班牙南部的山羊群中,MTC是广泛且分布不均的.
- 羊可能在该地区MTC的持续和传播中发挥着重要作用.
- 针对山羊的有效控制措施对于在这个热点地区管理结核病至关重要.
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