体重指数和多病症风险:系统性审查和剂量反应元分析
Jun Shan1, Rulan Yin2, Sirirat Panuthai3
1School of Nursing and Rehabilitation, Nantong University, China; Faculty of Nursing, Chiang Mai University, under the CMU presidential Scholarship, Thailand.
Archives of gerontology and geriatrics
|April 11, 2024
概括
较高的身体质量指数 (BMI) 与多重疾病风险的增加有关. 维持正常的BMI对于降低患多种慢性疾病的可能性至关重要.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 代谢健康 代谢健康
背景情况:
- 多病症,即两种或两种以上的慢性疾病的存在,构成了全球健康的重大挑战.
- 身体质量指数 (BMI) 是评估体重状况的广泛使用的指标,但其与多种疾病风险的确切关系需要进一步澄清.
研究的目的:
- 为了研究体质指数 (BMI) 和发展多病症的风险之间的剂量反应关系.
- 量化不同BMI类别 (体重不足,正常,超重,肥胖) 与多种疾病风险之间的关联.
主要方法:
- 在PubMed,CINAHL和Embase数据库的系统文献搜索,截至2023年1月25日.
- 包括研究BMI和多病症风险的原始文章.
- 应用随机效应模型和剂量反应元分析来估计95%置信区间 (CI) 的聚合几率比率 (OR).
主要成果:
- 对43项研究 (969,130名患者) 的元分析显示,与较高的BMI一起,多病症风险增加.
- 与正常BMI相比,超重 (OR=1.32) 和肥胖 (OR=1.93) 在纵向研究中显著增加了风险.
- 横截面研究显示了类似的趋势:超重 (OR=1.38) 和肥胖 (OR=2.38) 与更高的多重疾病风险有关.
结论:
- 增加BMI与增加多种疾病风险之间存在线性关联.
- 临床医生应监测患者的体重,并建议达到正常的BMI以减轻多病症.
- 公共卫生战略应侧重于体重管理,以减少多种慢性疾病的负担.
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