静止性低血压和认知障碍:纵向研究的系统综述和元分析
Guillaume T Duval1, Eve Raud1, Hugo Gohier1
1Department of Neuroscience, Division of Geriatric Medicine and Memory Clinic, UPRES EA 4638, UNAM, Angers University Hospital, Angers, France.
Maturitas
|April 11, 2024
概括
静止性低血压 (OH) 与较低的认知评分以及老年人认知障碍和痴呆的风险增加有关. 这一元分析证实了OH和认知衰退之间存在显著的关联.
科学领域:
- 老年学和认知神经学.
- 心血管健康和神经退行性疾病
背景情况:
- 静止性低血压 (OH) 和认知障碍之间的关系是复杂的,之前的研究产生了不一致的结果.
- 了解这种关联对于识别老年人群认知能力下降的风险因素至关重要.
研究的目的:
- 系统地审查和定量合成OH和认知功能之间的关联.
- 检查OH和迷你精神状态检查 (MMSE) 评分,认知障碍和事件痴呆症之间的联系.
主要方法:
- 在2022年5月进行了全面的Medline搜索,确定了15项符合选择标准的纵向研究.
- 对MMSE平均得分 (5项研究),OH和认知障碍 (5项研究) 以及OH和发病性痴呆症 (6项研究) 进行了元分析.
主要成果:
- 患有OH的个体表现出明显较低的MMSE平均得分 (-0.25,95%CI: -0.42至-0.07).
- 高血压与28%的认知障碍风险增加有关 (OR: 1.278,P < 0.0001).
- 高血压导致患痴呆症的风险增加了27% (HR: 1.267,P < 0.0001).
结论:
- 这一元分析证实了正静性低血压与老年人认知障碍之间的显著关联.
- 高血压与较差的认知表现和认知衰退和痴呆症的风险增加有关.
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