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Updated: Jun 28, 2025

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人类基因调节进化是由调节元件功能在cis和trans中的分歧驱动的

Tyler J Hansen1, Sarah L Fong2, Jessica K Day1

  • 1Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

Cell genomics
|April 11, 2024
PubMed
概括

物种之间的基因调节进化涉及当地cis和全球trans变化. 这项研究使用ATAC-STARR测序识别了成千上万种跨作用调节差异,揭示了它们与cis变化一起发挥的重要作用.

关键词:
DNA调节元件是DNA的调节元件.染色质可访问性 染色质可访问性进行比较的基因组学.增强活动增强活动.功能性基因组学 功能性基因组学基因调节 基因调节 基因调节人类进化人类的进化.淋巴细胞细胞系的细胞系.大规模并行记者分析.转录因子是一种转录因子.

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