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Updated: Jun 28, 2025

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突变FOXO1通过增强可访问性的增强器控制一个致癌网络

Hillary M Layden1, Jacob D Ellis1, Monica L Bomber1

  • 1Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

Cell genomics
|April 11, 2024
PubMed
概括

这项研究揭示了突变的FOXO1转录因子驱动器如何通过改变基因可访问性来扩散大B细胞淋巴瘤 (DLBCL). mFOXO1的快速降解确定了其直接目标,这对于理解DLBCL转录失调至关重要.

关键词:
在ATAC-seqq中使用.DLBCL DLBCL 是一个字母.这就是FOXO1的意义.这就是PRO-seqq.染色体重塑 染色体重塑的方法黑暗的区域是黑暗的区域.增强剂是一种增强剂.治疗药物 治疗药物

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