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Updated: Jun 28, 2025

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
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Published on: September 30, 2019

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开发基于SNAr电友的高强度和选择性共价FGFR4抑制剂

Moritz Schwarz1, Maksym Kurkunov1,2, Florian Wittlinger1

  • 1Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmaceutical Sciences, Eberhard Karls University Tübingen, 72076 Tübingen, Germany.

Journal of medicinal chemistry
|April 11, 2024
PubMed
概括

针对纤维细胞生长因子受体4 (FGFR4) 的新型共价抑制剂是使用SNAr化学开发的. 这些强效和选择性的FGFR4抑制剂对癌症治疗,特别是肝细胞癌症有很大的前景.

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