定义儿童发作狼的缓解:由国际工作组的PReS认可的共识定义
E M D Smith1, A Aggarwal2, J Ainsworth1
1Department of Women's & Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK; Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
Clinical immunology (Orlando, Fla.)
|April 11, 2024
概括
开发了儿童发病SLE (cSLE) 的新缓解定义. 这些标准旨在在儿科狼研究和临床实践中标准化治疗到点的方法.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 系统性红斑狼研究研究
- 临床试验设计 临床试验设计
背景情况:
- 儿童发病性SLE (cSLE) 需要特定的缓解标准才能有效管理.
- 现有的成人SLE定义可能无法完全捕捉儿科疾病细微差别.
- 标准化定义对于在cSLE中推进治疗到目标 (T2T) 策略至关重要.
研究的目的:
- 建立特定于cSLE的缓解定义.
- 为了支持未来的T2T临床试验和儿科狼的观察性研究.
- 为管理cSLE的临床实践提供指导.
主要方法:
- 使用了与儿科专家的Delphi调查,以收集有关成人SLE缓解目标的观点.
- 采用修改后的名义组技术来改进和同意cSLE缓解标准.
- 通过cSLE国际T2T工作组参与国际合作.
主要成果:
- 提出了两种不同的缓解定义:使用类固醇的cSLE临床缓解 (cCR) 和不使用类固醇的cSLE临床缓解 (cCR-0).
- 常见的标准包括临床SLE疾病活动指数 (SLEDAI-2K) 0和医生全球评估 (PGA) 分数<0.5.5.
- 特定的类固醇剂量标准区分cCR (≤0.1毫克/公斤/天,最大5毫克/天) 和cCR-0 (零).
结论:
- 开发了针对儿科患者群体量身定制的新型cSLE缓解定义.
- 确保与成人SLE缓解标准保持一致,以便进行终身研究.
- 这些定义为cSLE的一致评估和管理提供了基础.
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