来自Cordyceps militaris的五种未经描述的环
Wei Yang1, Cong Fu2, Bin-Yuan Hu2
1School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, PR China; Institute for Inheritance-Based Innovation of Chinese Medicine, Marshall Laboratory of Biomedical Engineering, School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen, 518055, PR China.
Phytochemistry
|April 11, 2024
概括
从Cordyceps militaris中分离出了五种新的环,Ustiloxins I-M,它们来自于Cordyceps militaris. 化合物4和5对人类三阴性乳腺癌细胞具有显著的毒性.
科学领域:
- 自然产品 化学 化学
- 药用化学 医学化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 军用菌 (Cordyceps militaris) 是一种以生产生物活性化合物而闻名的真菌.
- 环酸代表了一类具有多种生物活性的自然产品.
- 三阴性乳腺癌仍然是一个具有挑战性的疾病,目标治疗有限.
研究的目的:
- 从Cordyceps militaris中分离和表征新型环.
- 评估这些化合物的细胞毒性对人类三阴性乳腺癌细胞的影响.
主要方法:
- 使用染色学技术分离环.
- 使用光谱方法 (NMR,MS) 和X射线晶体学进行结构阐明.
- 结构赋值的计算方法.
- 在体外细胞毒性测定使用人类三阴性乳腺癌细胞系.
主要成果:
- 五种新的环酸,Ustiloxins I-M (1-5),被分离和表征.
- 通过结晶学证实了乌斯提洛辛I和M (1和5) 的结构.
- 通过光谱和计算分析确定了乌斯蒂洛辛J-L (2-4) 的结构.
- 乌斯提洛辛L (4) 和M (5) 对三阴性乳腺癌细胞具有细胞毒性,IC50值分别为64.29微米和28.89微米.
结论:
- 科迪塞普斯米利塔里斯 (Cordyceps militaris) 生产出具有潜在抗癌性能的新型环.
- 乌斯提洛辛L和M对人类三阴性乳腺癌细胞具有有前途的活性,需要进一步研究.
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