脑卒中后认知障碍的预测因素:VITATOPS认知子研究
Isabel Siow1, Kaavya Narasimhalu2, Keng Siang Lee3
1Ministry of Health Holdings Singapore, Singapore.
概括
脑卒中后认知障碍 (PSCI) 最常见的是影响亚洲人群的视觉构造和注意力. 高龄,低学历和后部循环中风是PSCI的关键预测因素.
科学领域:
- 神经学 神经学
- 认知科学 认知科学
- 脑卒中研究 脑卒中研究
背景情况:
- 脑卒中后认知障碍 (PSCI) 是继缺血性脑卒中后的常见并发症.
- 在PSCI中的认知缺陷因临床和中风相关因素而异.
- 识别与特定认知领域障碍相关的因素对于有针对性的干预至关重要.
研究的目的:
- 确定与特定认知领域的损伤相关的因素,以确定后缺血性中风的认知领域.
- 分析亚洲队列中PSCI的流行率和预测因素.
- 了解中风特征与认知衰退之间的关系.
主要方法:
- 利用了维生素预防中风 (VITATOPS) 试验副研究的数据.
- 包括连续患有缺血性中风或过渡性缺血性心脏病发作 (TIA) 的患者入住三级医院.
- 每年评估六个认知领域长达五年,使用考克斯比例危险模型.
主要成果:
- 在736名患者中,有23.5%患有认知障碍.
- 视觉构造 (26.4%) 和注意力 (19.8%) 是受影响最多的认知领域.
- 后循环大脑梗塞 (POCI),晚年,印第安人种族和低教育预测了特定的认知障碍.
结论:
- 视觉构造和注意力领域在这个亚洲PSCI队列中受到影响最大.
- 高龄,低学历,后部循环中风和并发症是独立的PSCI预测因素.
- 研究结果强调,需要根据中风类型和患者人口统计数据制定量身定制的治疗策略.
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