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由雄激素受体结合的DNA结合变化的基础结构机制

Xiao Yin Lee1, Wout Van Eynde2, Christine Helsen1

  • 1Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, Campus Gasthuisberg ON1 Herestraat 49 - box 901, Leuven 3000, Belgium.

The Journal of steroid biochemistry and molecular biology
|April 11, 2024
PubMed
概括

雄激素受体 (AR) DNA结合域 (DBD) 在DNA上形成头对头的二极体,解释了突变如何影响AR功能和结合亲和力. 这种结构洞察力揭示了合作的DNA结合机制.

关键词:
雄激素受体的受体 雄激素受体雄激素反应元素的雄激素反应元素.晶体结构 晶体结构的DNA结合域域.分子动力学模拟模型在X射线晶体学.

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