开始性皮肤细菌 加剧炎症并延迟皮肤屏障的修复
Veda D Khadka1, Laura Markey1, Magalie Boucher2
1Institute for Medical Engineering & Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; Department of Civil and Environmental Engineering, School of Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
The Journal of investigative dermatology
|April 11, 2024
概括
将像Staphylococcus epidermidis这样的开始性皮肤细菌应用于损伤的皮肤,延迟了伤口愈合和增加了炎症. 这表明在开发皮肤微生物作为修复屏障的益生菌时需要谨慎.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
背景情况:
- 皮肤微生物组发挥着双重作用,提供免疫保护,但也构成感染风险.
- 斯塔菲洛科克斯 (Staphylococcus epidermidis) 的殖民可以保护小鼠皮肤免受伤口和病原体的影响.
- 同时的皮肤损伤和共生微生物暴露的影响,特别是对益生菌的发展,仍然不清楚.
研究的目的:
- 调查高剂量开始性皮肤细菌应用对磨损皮肤屏障修复的影响.
- 了解伤口愈合期间对开始性皮肤微生物的炎症和细胞反应.
主要方法:
- 磨损的小鼠皮肤被高剂量的共生细菌治疗,包括Staphylococcus epidermidis和Staphylococcus xylosus.
- 随着时间的推移,评估了皮肤屏障的修复.
- 分析了炎症,中性粒细胞透,纤维细胞活性和单细胞分化.
- 进行了转录基因分析,以确定涉及的分子途径.
主要成果:
- 皮肤微生物组的抗生素耗尽延迟修复.
- 包括S. epidermidis在内的共生动物的益生菌类应用,显著延迟了皮肤屏障的修复.
- 暴露于S. epidermidis引起了快速和持久的炎症,其特征是中性粒细胞和纤维细胞活性增加.
- 转录组数据表明,上调的增殖途径阻碍了修复的进展.
结论:
- 高剂量的开始性皮肤细菌可以阻碍而不是促进皮肤屏障的修复.
- 即使使用益生菌,也可能导致有害的炎症反应和慢性类似伤口的状态.
- 需要进一步的研究来了解皮肤微生物组和伤口愈合之间的复杂相互作用,以确保安全的益生菌发展.
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