运动训练模式对健康成年人肌酸激素表达的影响:通过元分析进行系统性审查
Francesco Bettariga1, Dennis R Taaffe1, Daniel A Galvão1
1Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA 6027, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA 6027, Australia.
运动会影响肌肉激素水平,但由于研究异质性,精确的结论是有限的. 需要进一步的研究来了解运动模式和肌反应.
科学领域:
- 运动生理学 运动生理学
- 分子生物学分子生物学
- 内分泌学 在内分泌学.
背景情况:
- 骨肌肉释放myokines,关键的信号蛋白调解器官间的通信.
- 肌基因影响许多生理过程,包括炎症,新陈代谢和癌症抑制.
- 了解运动对肌肉激素的影响对于临床应用至关重要.
研究的目的:
- 系统地审查和元分析运动对特定肌动因的影响.
- 为了比较肌酸对有氧运动和抵抗运动的反应.
- 为了阐明运动后肌肉激素表达的时间动态.
主要方法:
- 在六个主要数据库中进行系统的文献搜索 (2023年4月).
- 包括测量互白素-15 (IL-15),虹膜素,SPARC,OSM和色素的研究.
- 随机效应的元分析,以量化肌水平的变化.
主要成果:
- 分析了62项研究 (n=1193),表明运动通常会增加肌肉激素的表达.
- 无论是有氧运动还是阻力运动,都会诱导肌肉激素的变化,模式之间没有显著差异.
- 24小时内肌水平恢复到基线,但由于异质性,大多数变化缺乏统计学意义.
结论:
- 目前关于运动诱导的肌肉激素变化的知识有限,但越来越多.
- 研究设计和测量的显著异质性阻碍了最终的结论.
- 进一步的研究是必不可少的,以澄清不同的炼方式和时间点对肌肉蛋白反应的影响.
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