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在糖尿病视网膜病变中视网膜层失调和视觉功能障碍的严重程度

Stela Vujosevic¹, Camilla Alovisi², Gabriele Piccoli³

¹Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy; Eye Clinic, IRCCS MultiMedica, Milan, Italy.

Ophthalmology. Retina

|April 11, 2024

概括

带有视网膜失调的糖尿病视网膜病变 (DR) 显著损害视力和视网膜敏感性. 外层损伤和缺血严重程度预测视觉功能丧失,这表明DR进展的潜在生物标志物.

科学领域:

眼科医生眼科眼科
医疗成像医学成像
视网膜疾病视网膜疾病

背景情况:

糖尿病视网膜病变 (DR) 可以导致视网膜的结构变化.
视网膜内外层 (DRIL/DROL) 的失调和缺血是DR的关键病理特征.
评估这些结构变化对视觉功能的影响对于了解DR严重程度至关重要.

研究的目的:

评估视网膜内外层 (DRIL/DROL) 失调和缺血对糖尿病视网膜病变 (DR) 视敏度和视网膜敏感性的影响.
为了将微观测量 (MP) 和OCT/OCT血管学 (OCTA) 的发现与DR患者视网膜失调和缺血的严重程度相关联.

主要方法:

一项回顾性病例控制研究分析了65名DR患者的76只眼睛.
使用OCT/OCTA和微波测量 (MP) 来分级视网膜失调 (DRIL/DROL),评估视网膜敏感度 (RS) 和最佳校正视敏度 (BCVA).
图像分析软件 (图像J,MATLAB) 用于视网膜结构和功能的定位.

主要成果:

与对照组相比,DRIL/DROL和缺血症患者的BCVA,整体视网膜敏感度 (oRS) 和血管密度降低显著.
视网膜失调程度的增加与RS和BCVA的减少以及胆管膜流空隙 (CC-FVs) 的增加相关.
视网膜灵敏度和CC-FV是DR失调度 (R2 = 0.45) 的显著预测因素;固定稳定性恶化与DRIL/DROL严重性相关.

结论:

微波测量和BCVA表明DR患者视网膜失调的视觉功能下降,特别是当外层和光受体受到影响时.
视网膜失调和缺血的严重程度可以作为糖尿病视网膜病变中功能障碍的潜在生物标志物.

关键词:

生物标志物生物标志物糖尿病视网膜病变 - 糖尿病视网膜病变视网膜层的不组织.斑点性缺血症斑点性缺血症是什么微观测量仪的使用方法

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