在退伍军人中患有部署后呼吸综合征的肺血管疾病
Sergey S Gutor1, Bradley W Richmond2, Vineet Agrawal3
1Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN.
概括
带有纤维化的肺血管疾病 (PVD) 在退伍军人中常见,他们患有部署后呼吸系统综合征 (PDRS). 这种PVD可能会导致肺高血压 (PH),导致受影响的服务人员的运动呼吸障碍和运动限制.
科学领域:
- 心血管医学 心血管医学
- 肺部医学 肺部医学
- 军人卫生保健 军人卫生保健
背景情况:
- 劳动性呼吸障碍是从部署返回的美国军人中常见的抱怨.
- 部署后呼吸系统综合征 (PDRS) 是这个人群中公认的疾病.
- 在PDRS中持续性劳动性呼吸障碍的潜在原因尚未完全理解.
研究的目的:
- 调查PDRS的退伍军人的运动性呼吸障碍和肺血管疾病 (PVD) 之间的关联.
- 为了描述受影响的退伍军人的肺血管结构中的组织形态测量变化.
- 为了评估这些退伍军人的子集中的肺高血压 (PH) 的存在.
主要方法:
- 在52名经过活检证明的PDRS的退伍军人中,与对照人群相比,肺血管组织组形测量.
- 对五名患有PDRS和持续性劳动性呼吸障碍的退伍军人进行临床随访.
- 在随访中包括症状问卷,肺功能测试,心声回声和右心导管 (RHC).
主要成果:
- 在PDRS退伍军人的肺动脉中纤维化时显著增加内膜和介质厚度.
- 在PDRS退伍军人的肺静脉中纤维化增加了亲密和冒险的厚度.
- 在5名跟踪的退伍军人中,有3名表现出右心室扩大和RHC上PH的证据.
结论:
- 肺血管疾病 (PVD),以静脉纤维化为特征,在PDRS中很普遍.
- 肺高血压 (PH) 的发展可能是导致一些PDRS退伍军人的运动呼吸障碍和运动限制的一个重要因素.
- 这些发现凸显了在经历部署后持续呼吸道症状的退伍军人中评估PVD和PH的重要性.
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