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EVPsort:在细胞外囊泡和粒子中进行小型ncRNA剖析和分类的地图

Hua-Chang Chen¹, Jing Wang¹, Robert J Coffey²

¹Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Journal of molecular biology

|April 11, 2024

概括

细胞外囊泡和粒子 (EVPs) 携带小非编码RNA (ncRNAs),对于细胞通信至关重要. EVPsort数据库提供了全面的ncRNA分析和分类分析,以推进临床应用.

科学领域:

生物化学生物化学
分子生物学分子生物学
生物信息学是一种生物信息学.

背景情况:

细胞外囊泡和粒子 (EVPs) 通过分子载荷调解细胞间的细胞间通信.
EVP中的小型非编码RNA (ncRNA) 对生物过程具有重要意义.
了解ncRNA的丰富性和EVP的分类对于临床翻译至关重要.

研究的目的:

开发一个全面的资源,以在EVP中进行ncRNA分析.
研究EVP中的ncRNA排序机制.
为了促进ncRNA功能和临床相关性的探索.

主要方法:

开发了EVPsort数据库的开发.
整合了来自不同来源的3,162个EVP样本.
整合了19个外部数据库和用于全面分析的工具.

主要成果:

EVPsort 在各种条件下提供了广泛的ncRNA分析.
该数据库允许对ncRNA分类,RNA结合蛋白 (RBP) 关联以及动机识别进行调查.
评估功能影响,包括目标,途径,疾病和药物.

结论:

EVPsort是一个开创性的数据库,用于研究ncRNA的丰富性和EVP的排序.
它为分析ncRNA配置文件及其功能角色提供了强大的工具.
该资源支持旨在推进EVP和ncRNAs临床应用的研究.

关键词:

在RBP/motif-miRNA中使用.细胞外囊泡和颗粒 (EVP)在 miRNA 基因/通路上.小ncRNA分析和分类

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