基宁受体在皮肤色素中的作用
Juliana de Cassia Pinto Ferreira1, Bruna Silva Soley1, Priscila Lucia Pawloski1
1Department of Pharmacology, Universidade Federal do Paraná, Curitiba, PR, Brazil.
European journal of pharmacology
|April 11, 2024
概括
素系统在皮肤颜色中起作用. 阻断素受体 (B1R,B2R) 恶化了单素诱导的色素减退,并改变了黑色素水平,这表明它们参与了皮肤颜色调节.
科学领域:
- 皮肤病学 皮肤病学
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
背景情况:
- 基宁系统存在于正常和炎症皮肤中,在生理和病理过程中发挥作用.
- 它对皮肤颜色和相关疾病的参与尚未完全理解.
研究的目的:
- 为了研究素在单 (MBZ) 诱导的白风样皮肤脱色的作用.
- 阐明因受体 (B1R,B2R) 在皮肤色素化通路中的功能.
主要方法:
- 使用素受体淘汰赛小鼠 (KOB1R,KOB2R,KOB1B2R) 和野生类型 (WT) 的小鼠.
- 给药的单子 (MBZ) 诱导一种类似白风的模式.
- 评估了皮肤脱色,黑色素含量,活性氧物种 (ROS) 生成,皮肤细胞透和细胞因子水平 (IL-4,IL-6,IL-17,TNF,IL-1).
- 在B16F10细胞上使用B1R和B2R激动剂和布拉迪基宁进行了体外测定.
主要成果:
- 与WT相比,MBZ在KOB1R,KOB2R和KOB1B2R小鼠中诱导了较大的色素丧失.
- 在MBZ治疗后,KOB1R和KOB2R小鼠的黑色素和ROS水平降低.
- 缺少B1R和B2R导致皮肤细胞透率增加,并改变了炎症性细胞因子配置.
- 在体外,B1R和B2R激动剂增加了细胞内黑色素,而布拉迪基宁增强了细胞外黑色素和细胞增殖.
结论:
- 缺乏因受体会加剧MBZ诱导的皮肤脱色.
- B1/B2受体的遗传删除会影响构成性黑色素水平.
- 素系统与关键的皮肤色素化途径有关.
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