超越症状:无症状Mycobacterium avium复杂肺部感染的放射性鉴定
Keiji Fujiwara1, Fumiya Watanabe2, Fumiko Uesugi3
1Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan; Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan; Department of Basic Mycobacteriosis, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
无症状的Mycobacterium avium复杂性肺部感染 (MAC-PI) 经常在例行检查期间检测到. 尽管缺乏症状,但这些患者可能会有进展,这凸显了所有MAC-PI病例需要及时管理的必要性.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 非结核性菌根性肺病 (NTM-PD) 准则强调症状的存在.
- 无症状的Mycobacterium avium复杂性肺部感染 (MAC-PI) 的临床特征尚未得到研究.
- 这项研究旨在澄清无症状MAC-PI的临床特征和进展.
研究的目的:
- 为了比较无症状MAC-PI患者和症状患者的临床特征和病程.
- 确定影响无症状MAC-PI患者开始治疗的因素.
主要方法:
- 连续200名符合NTM-PD标准的MAC-PI患者的回顾性分析.
- 症状和无症状组之间的临床特征和结果的比较.
- 多变量分析以确定治疗开始的预测因素.
主要成果:
- 89名患者在诊断时无症状;15.7%患有腔腔病变.
- 无症状患者开始治疗的独立风险因素包括腔腔病变,阳性酸快细菌涂抹和年龄较小.
- 57.9%的无症状患者出现疾病进展,34.2%的无症状患者呈现放射性进展,但症状没有恶化.
结论:
- 常规健康检查可以在无症状个体中检测出重要的MAC-PI.
- 无症状MAC-PI的临床过程与症状病例相似.
- 及时的管理和干预对于所有MAC-PI患者来说至关重要,无论症状如何.
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