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异质环境中的化学反应:一个分散收集过去障碍的多代理模型

Daniele Proverbio¹

¹Department of Industrial Engineering, University of Trento, 9 via Sommarive, 38123 Trento, Italy.

Journal of theoretical biology

|April 11, 2024

概括

微生物细胞迁移,或化疗,可以克服环境障碍. 简单的个体行为和社会互动使得强大的殖民地聚集,即使没有专门的避难障碍.

科学领域:

微生物学微生物学
生物物理学的生物物理.
计算生物学计算生物学

背景情况:

化学反应,或沿着化学梯度的细胞迁移,驱动微生物的自我组织.
在复杂,异质的环境中模拟化学反应仍然是一个挑战.

研究的目的:

分析在具有物理和化学障碍的环境中分散的细胞聚集.
研究社会互动和个体细胞行为在克服障碍方面的作用.

主要方法:

使用Dictyostelium discoideum殖民地的多剂型模型.
采用拓独立度量来量化系统演变.
分析复杂的社会相互作用中出现的动态特征.

主要成果:

障碍物通过破坏化学信号流来阻碍收集,作为拓扰动.
通过最小的代理规则可以实现强大的收集,不需要明确的障碍物传感.
随机的细胞移动可以防止多个稳定集群,并提高整体集群的有效性.

结论:

化疗细胞可以在没有专门的回避机制的情况下通过障碍物进行导航.
社会互动和个体波动之间的权衡足以使殖民地聚集越过障碍.

关键词:

集体行为集体行为不同质的环境不同质的环境微生物系统微生物系统多代理模型建模.模式形成的形成模式.

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