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日本的积极和被动吸烟和乳腺癌:对九项基于人口的队列研究进行了综合分析
Keiko Wada1, Chisato Nagata1, Mai Utada2
1Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
International journal of epidemiology
|April 11, 2024
概括
吸烟可能会增加绝经前乳腺癌的风险,尤其是在生命早期开始吸烟时. 在这项研究中,二手烟暴露与乳腺癌没有关联.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 流行病学研究对吸烟与乳腺癌的联系提出了相互矛盾的发现.
- 生物学机制表明,吸烟和乳腺癌之间存在潜在的积极关联.
研究的目的:
- 为了研究活跃和被动吸烟与乳腺癌风险之间的关联,在一个大型的日本队列.
- 为了确定吸烟开始的年龄或与分娩相对的时间是否会影响乳腺癌风险.
主要方法:
- 分析了9项日本前性队列研究 (1984-2006) 中166611名女性的数据.
- 通过基线问卷收集有关吸烟和二手烟暴露的信息.
- 考克斯回归和随机效应的元分析用于计算乳腺癌的危险比率,调整为混因素.
主要成果:
- 与从未吸烟者相比,目前吸烟者在50岁之前患乳腺癌的风险较高.
- 早期开始吸烟 (30岁或第一次分娩前) 与更年期前乳腺癌风险增加有关.
- 在二手烟暴露和乳腺癌风险之间没有发现显著的关联.
结论:
- 积极吸烟,特别是早期开始吸烟时,可能会增加更年期前乳腺癌的风险.
- 需要进一步的研究才能充分了解二手烟对乳腺癌发展的影响.
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