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Updated: May 12, 2026

Engineering Skeletal Muscle Tissues from Murine Myoblast Progenitor Cells and Application of Electrical Stimulation
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骨形态遗传蛋白信号抑制剂改善了使用C2C12制造的3D肌肉结构的差异化和功能

Ran Ding1, Yuan Xi1, Akira Ito2

  • 1Graduate School of Human and Environmental, Kyoto University, Yoshida-Konoe-Cho, Sakyo-ku, Kyoto 606-8507, Japan.

Journal of bioscience and bioengineering
|April 11, 2024
PubMed
概括

研究人员开发了一种新的方法,使用自我组织和骨形态遗传蛋白 (BMP) 抑制剂来创建人工骨肌肉组织. 这种技术增强了肌肉细胞的分化和功能,为药物发现和研究提供了有前途的工具.

关键词:
骨形态遗传蛋白质抑制剂 骨形态遗传蛋白质抑制剂在C2C12单元中,单元格为C2C12.细胞外矩阵是细胞外矩阵.骨肌肉组织工程 骨肌肉组织工程硬性 这是一种硬性.

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Formation of Muscle Fibers from Myoblasts

De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription factors...