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Published on: November 10, 2023

在SARS-CoV-2感染后,研究急性后遗症的研究进展

Taiwei Jiao¹, Yuling Huang², Haiyan Sun³

¹Department of Gastroenterology and Endoscopy, The First Hospital of China Medical University, Shenyang, Liaoning, 110001, P.R. China.

Cell death & disease

|April 11, 2024

概括

在SARS-CoV-2感染 (PASC) 或长期COVID后的后急性后果,呈现出影响多个器官系统的多种健康问题. 本综述涵盖了PASC并发症,机制,诊断和治疗,以改善患者的治疗结果.

科学领域:

传染性疾病传染性疾病
肺部病理学肺部病理学
神经学神经学
心脏病学心脏病学
内分泌学在内分泌学.
免疫学免疫学免疫学

背景情况:

广泛的SARS-CoV-2流行病导致全球数百万人感染.
有相当数量的患者经历了急性COVID-19后的持续症状和并发症,称为SARS-CoV-2感染 (PASC) 或长期COVID后的急性后续症.
帕斯克是一种影响多个器官系统的异质性疾病,构成了日益严重的全球健康挑战.

研究的目的:

提供与COVID-19相关的长期并发症和后果的全面审查.
阐明PASC背后的病理生理机制.
概述目前用于管理PASC的诊断方法和治疗策略.

主要方法:

对PASC研究的系统文献综述.
分析报告的各种器官系统的长期并发症.
综合有关PASC病理生理学,诊断和治疗的信息.

主要成果:

PASC表现为广泛的症状,影响呼吸,心血管,神经,内分泌和其他系统.
潜在的病理生理机制包括持续的病毒活动,免疫失调,自身免疫反应和器官损伤.
由于症状异质性和缺乏特定生物标志物,存在诊断挑战.

结论:

PASC是一种复杂而多面的疾病,需要多学科的管理.
提高认识和标准化的诊断和治疗方案对于优化长期COVID患者的护理至关重要.
需要进一步的研究,以充分了解PASC的机制,并开发有针对性的疗法.

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