合理设计的益生菌可以通过益生菌-肠道微生物-免疫轴来预防白综合征
Haonan Sha1,2, Jiaqi Lu1,2, Jiong Chen1,2
1State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Insititute of Plant Virology, Ningbo University, Ningbo, 315211, China.
NPJ biofilms and microbiomes
|April 11, 2024
概括
这项研究证实了多种Vibrio物种和白便综合征 (WFS) 之间的因果关系. 研究人员设计了特定的益生菌,通过调节肠道微生物群和增强免疫力,有效地保护免受WFS的侵害.
科学领域:
- 水产养殖是水产养殖的一种方式.
- 微生物学 微生物学
- 动物健康 动物健康
背景情况:
- 像白综合症 (WFS) 这样的复杂疾病通常与共同感染有关,但缺乏实验验证.
- 这种知识差距阻碍了开发有效的益生菌来抵抗病的发展.
研究的目的:
- 通过实验验证特定Vibrio物种在WFS病因中的因果作用.
- 理性地设计和测试一种多菌株益生菌配方,用于在中预防WFS.
主要方法:
- 考赫的假设被应用来确认中的Vibrio fluvialis,V. coralliilyticus和V. tubiashii的致病性.
- 选择了四种对抗性细菌菌株,并将它们配制成益生菌混合物 (Ruegeria lacuscaerulensis,Nioella nitratireducens,Bacillus subtilis和Streptomyces euryhalinus).
- 分析了益生菌补充对肠道微生物群,宿主免疫力和WFS耐药性的影响.
主要成果:
- 三种Vibrio物种的联合感染被证实是WFS的原因,符合科赫的假设.
- 设计的益生菌混合物显著保护了对WFS的.
- 益生菌调节了肠道微生物群,增强了有益的种群和代谢功能,同时加强了生态和机械障碍.
- 益生菌补充激活了的关键免疫路径,包括Fcγ R介导的细胞分裂,Toll类受体和RIG-I类受体信号传递.
结论:
- 这项研究为验证多病原体共感染和设计向益生菌提供了一个框架.
- 开发的益生菌通过优化肠道微生物群和宿主免疫力,为管理WFS提供了一个有希望的策略.
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