胃神经内分泌瘤的发生
Giuseppe Lamberti1,2, Francesco Panzuto3,4, Marianne Pavel5
1Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum - University of Bologna, Bologna, Italy.
Nature reviews. Disease primers
|April 11, 2024
概括
胃神经内分泌瘤 (gNENs) 正在增加. 不同类型的gNEN需要不同的管理策略,强调需要更好地了解它们的病理生理学.
科学领域:
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
背景情况:
- 胃神经内分泌瘤 (gNENs) 呈现出独特的特定部位特征.
- 近几十年来,gNEN的发病率和患病率显著增加.
- gNEN包括胃神经内分泌癌 (gNECs) 和胃神经内分泌瘤 (gNETs),gNETs进一步分为三种不同的类型.
研究的目的:
- 审查胃神经内分泌瘤的分类和独特的临床特征.
- 概述不同gNEN亚型所需的各种多学科管理方法.
- 强调需要对gNEN病理生理学有更好的理解,以改善患者的治疗结果.
主要方法:
- 对胃神经内分泌新生瘤现有文献的综述.
- 对gNETs和gNECs的分类系统的分析.
- 根据瘤类型和临床表现,讨论当前的治疗方法.
主要成果:
- I型和II型的gNET依赖于胃素,与慢性缩性胃炎或Zollinger-Ellison综合征/MEN1有关.
- 在各种胃粘膜条件下,III型gNETs在没有超胃血的情况下发生.
- gNECs可以在不同的胃环境中产生,并且由于转移潜力,通常需要全身治疗.
结论:
- 每个gNEN亚型都需要一个定制的,多学科的方法.
- 目前关于gNEN的系统性治疗数据通常是从肠道NEN和NEC推断出来的.
- 对gNENs分子和临床病理生理学的进一步研究对于推进患者护理至关重要.
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