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Updated: Jun 28, 2025

Oligopeptide Competition Assay for Phosphorylation Site Determination
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人类酸化部位的致病突变会影响蛋白质与蛋白质相互作用

Trendelina Rrustemi1, Katrina Meyer1,2, Yvette Roske1

  • 1Max Delbrück Center (MDC), Robert-Rössle-Str. 10, 13125, Berlin, Germany.

Nature communications
|April 11, 2024
PubMed
概括

固有无序蛋白区域 (IDR) 的致病突变通过改变酸化依赖的短线性基因 (SLiM) 来破坏关键蛋白-蛋白相互作用 (PPI). 这会影响细胞功能和疾病机制.

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Phosphorylation01:02

Phosphorylation

The addition or removal of phosphate groups from proteins is the most common chemical modification that regulates cellular processes. These modifications can affect the structure, activity, stability, and localization of proteins within cells as well as their interactions with other proteins.
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Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
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