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Updated: Jun 28, 2025

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
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Published on: July 14, 2015

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在蛋白质领域的进化和种群约束的统一分析突出了结构特征和病原性位点

Stuart A MacGowan1, Fábio Madeira1,2, Thiago Britto-Borges1,3

  • 1Division of Computational Biology School of Life Sciences University of Dundee, Dow Street Dundee, DD1 5EH, Scotland, UK.

Communications biology
|April 11, 2024
PubMed
概括

人群测序揭示了残留水平蛋白质约束,补充了进化数据. 这种新的Missense丰富分数 (MES) 有助于预测蛋白质结构和识别病原体位点.

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