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Updated: Jun 28, 2025

In Vitro Analysis of E3 Ubiquitin Ligase Function
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通过1.8 MDa的CUL9 E3结合酶复合体的非正规组合,化和仿真的库林-RING/RBR无处不在

Daniel Horn-Ghetko1, Linus V M Hopf1,2, Ishita Tripathi-Giesgen1,2

  • 1Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Martinsried, Germany.

Nature structural & molecular biology
|April 11, 2024
PubMed
概括

CUL9-RBX1复合体独特地结合了cullin-RING和RBR域,使其无处不在. 这种特定于脊椎动物的E3结合酶使用化来激活,揭示了全方位转移的新机制.

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